Table 3 Binary classification of diseases based on all the brain structures.

From: Comparative validation of AI and non-AI methods in MRI volumetry to diagnose Parkinsonian syndromes

Case

V-Net

UNETR

FS

LR

XGBoost

LR

XGBoost

LR

XGBoost

Normal vs. PSP

\(\mathbf {0.89\pm 0.07}\)

\({0.86\pm 0.05}\)

\({0.89\pm 0.08}\)

\({0.84\pm 0.04}\)

\(\mathbf {0.89\pm 0.07}\)

\({0.87\pm 0.06}\)

Normal vs. MSA-P

\({0.78\pm 0.04}\)

\({0.73\pm 0.003}^*\)

\(\mathbf {0.81\pm 0.03}\)

\({0.77\pm 0.04}\)

\({0.79\pm 0.001}\)

\(\mathbf {0.82\pm 0.01}\)

Normal vs. MSA-C

\({0.90\pm 0.03}\)

\(\mathbf {0.93\pm 0.04}\)

\({0.85\pm 0.12}\)

\({0.90\pm 0.10}\)

\({0.88\pm 0.04}\)

\(\mathbf {0.95\pm 0.03}\)

Normal vs. PD

\({0.60\pm 0.07}\)

\(\mathbf {0.66\pm 0.02}^*\)

\({0.60\pm 0.04}\)

\({0.60\pm 0.03}\)

\({0.65\pm 0.07}\)

\(\mathbf {0.70\pm 0.05}\)

PD vs. PSP

\(\mathbf {0.80\pm 0.08}\)

\({0.78\pm 0.001}^*\)

\({0.77\pm 0.13}\)

\({0.75\pm 0.01}\)

\(\mathbf {0.77\pm 0.10}\)

\({0.76\pm 0.03}\)

PD vs. MSA-P

\(\mathbf {0.76\pm 0.07}\)

\({0.66\pm 0.03}\)

\({0.71\pm 0.02}^*\)

\({0.68\pm 0.07}^*\)

\(\mathbf {0.79\pm 0.08}\)

\({0.71\pm 0.02}\)

PD vs. MSA-C

\(\mathbf {0.91\pm 0.04}\)

\({0.87\pm 0.03}\)

\({0.80\pm 0.19}\)

\({0.80\pm 0.12}\)

\({0.89\pm 0.07}\)

\(\mathbf {0.91\pm 0.05}\)

  1. AUC in LR and XGBoost of CNN-based V-Net, ViT-based UNETR, and FS. The AUC is expressed as the mean from threefold cross-validation. LR; logistic regression, XGBoost; eXtreme Gradient Boosting.
  2. The best result for each volume segmentation method based on FS and DL in each binary classification is shown in bold.
  3. *\(p < 0.05\) indicates a significant difference in AUC between the DL models and FS.