Table 1 EnrichR Pathway analysis of differentially-expressed genes between Afr + Asi/DM cybrids cultured in room air versus 2% oxygen.
From: Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids
African and Asian [Afr + Asi] DM, hypoxia versus room air | |||||
|---|---|---|---|---|---|
Rank | Term | Overlap | Adjusted p-value | Z-score | Combined score |
1 | Ribosome_Homo sapiens_hsa03010 | 83/137 | 3.36816E−21 | − 1.74614 | 92.23118 |
2 | Metabolic pathways_Homo sapiens_hsa01100 | 378/1239 | 1.30460E−13 | − 1.98676 | 68.85048 |
3 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 70/169 | 1.77845E−07 | − 1.76655 | 35.54995 |
4 | Carbon metabolism_Homo sapiens_hsa01200 | 49/113 | 6.29999E−06 | − 1.63462 | 26.59338 |
5 | Lysosome_Homo sapiens_hsa04142 | 50/123 | 4.15835E−05 | − 1.67413 | 23.70320 |
6 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 25/48 | 1.09485E−04 | − 1.77390 | 23.07510 |
7 | TNF signaling pathway_Homo sapiens_hsa04668 | 43/110 | 5.61712E−04 | − 1.75310 | 19.66767 |
8 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 45/120 | 9.57908E−04 | − 1.67261 | 17.45152 |
9 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 38/98 | 1.15460E−03 | − 1.66358 | 16.43489 |
10 | Fatty acid metabolism_Homo sapiens_hsa01212 | 23/48 | 9.70756E−04 | − 1.45318 | 14.98963 |
11 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 39/103 | 1.39184E−03 | − 1.43983 | 13.65642 |
12 | Insulin resistance_Homo sapiens_hsa04931 | 40/109 | 2.37148E−03 | − 1.43738 | 12.78004 |
18 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 36/101 | 7.02269E−03 | − 1.43281 | 10.75077 |
25 | Endocytosis_Homo sapiens_hsa04144 | 75/259 | 1.54455E−02 | − 1.17626 | 7.47406 |
34 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 43/137 | 2.17697E−02 | − 0.66996 | 3.84699 |
