Table 2 EnrichR pathway analysis of differentially-expressed genes between Euro/DM cybrids cultured in room air versus 2% oxygen.
From: Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids
European (Euro) DM, Hypoxia versus room air | |||||
|---|---|---|---|---|---|
Rank | Term | Overlap | Adjusted p-value | Z-score | Combined score |
1 | Ribosome_Homo sapiens_hsa03010 | 85/137 | 1.47075E−21 | − 1.74614 | 93.67801 |
2 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 71/169 | 5.56805E−07 | − 1.79043 | 34.71290 |
3 | Metabolic pathways_Homo sapiens_hsa01100 | 352/1239 | 2.40768E−06 | − 1.96192 | 34.36975 |
4 | Carbon metabolism_Homo sapiens_hsa01200 | 46/113 | 4.07692E−04 | − 1.63462 | 19.77707 |
5 | Endocytosis_Homo sapiens_hsa04144 | 84/259 | 2.87911E−03 | − 1.83881 | 17.86864 |
6 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 39/101 | 3.61021E−03 | − 1.83334 | 16.69610 |
7 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 51/137 | 2.00388E−03 | − 1.54990 | 15.93823 |
8 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 40/103 | 2.87911E−03 | − 1.65506 | 15.64200 |
9 | Lysosome_Homo sapiens_hsa04142 | 46/123 | 2.87911E−03 | − 1.62388 | 15.51125 |
10 | Insulin resistance_Homo sapiens_hsa04931 | 41/109 | 3.93832E−03 | − 1.59642 | 14.07932 |
85 | Fatty acid metabolism_Homo sapiens_hsa01212 | 18/48 | 6.91730E−02 | 0.12171 | − 0.55465 |
