Table 2 Location and statistics of epistatic effects on node-level FC metrics, reported for each ROI that result significantly and non-significantly influenced by epistatic effect.

From: Environmental effects on brain functional networks in a juvenile twin population

Node-level FC metric

ROIs

Z-statistics

p-values

Strength of positive weights

Frontal Inf Orb L

Z = 1.2159

n.s

Frontal Inf Orb R

Z = 1.7323

p = 0.0416

Amygdala, R

Z = 1.4793

n.s

Occipital Inf L

Z = 0.3426

n.s

Paracentral Lobule L

Z = 0.9264

n.s

Paracentral Lobule R

Z = 0.9295

n.s

Heschl L

Z = 0.8185

n.s

Temporal Pole Sup R

Z = 1.2350

n.s

Temporal Pole_Mid L

Z = 0.4449

n.s

Strength of negative weights

Cingulum Ant R

Z = 1.1804

n.s

Cingulum Mid L

Z = 1.3585

n.s

Cingulum Mid R

Z = 0.8367

n.s

Parietal Inf L

Z = 0.5618

n.s

Precuneus L

Z = 0.6659

n.s

Temporal_Inf_R

Z = 4.2472

p < 0.001

Degree

Precentral R

Z = 1.0946

n.s

Olfactory L

Z = 0.8336

n.s

ParaHippocampal R

Z = 0.2017

n.s

Amygdala R

Z = 2.0414

p = 0.0206

Lingual R

Z = 0.9892

n.s

Fusiform L

Z = 0.4646

n.s

Postcentral R

Z = 0.7843

n.s

Paracentral Lobule L

Z = 1.2837

n.s

Temporal Mid L

Z = 0.4837

n.s

Temporal Inf R

Z = 0.9516

n.s

Local efficiency

Rolandic Operculum L

Z = 0.5786

n.s

Insula L

Z = 0.7832

n.s

Temporal Mid L

Z = 1.2738

n.s

Clustering coefficient

Frontal Mid Orb R

Z = 1.6853

p = 0.0406

Rolandic Operculum L

Z = 0.6179

n.s

Insula R

Z = 0.9402

n.s

Cuneus R

Z = 1.0720

n.s

Paracentral Lobule L

Z = 0.5233

n.s

Caudate_L

Z = 0.9640

n.s

Betweenness centrality

Frontal Mid Orb R

Z = 0.7991

n.s

Lingual L

Z = 0.6765

n.s

Parietal Sup R

Z = 0.7678

n.s

Temporal Pole Sup L

Z = 0.0919

n.s

  1. Orb, orbital part; Inf, inferior part; Mid, middle or median part; Sup, superior part, R, right; L, left; Post, posterior part; Ant, anterior part; FC, functional connectivity; Z: Fisher’s Z statistics; n.s., not significant. P-values surviving the Bonferroni correction are bolded.