Table 1 Characteristic of all included literature.
First author | Year | Country | FS/FN/control (number of samples) | Case/control age | Tissue | Detection methods | Time of collection | Type of study | Selection | Comparability | Exposure/result | Total score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mehmet et al.12 | 2021 | Turkey | 40/13/45 | All children: 6 months–6 years old | CSF | ELISA | Within the first 24 h after the seizure | Case-control | ★★★★ | ★★ | ★★ | 8 |
Jinglin et al.13 | 2021 | China | 90/0/60 | FS group: 34.04±9.54 months; healthy control: 35.45±10.32 months | BLOOD | ELISA | The FS group was collected on an empty stomach within 24 h after admission, and the healthy control group was collected on an empty stomach in the morning of the physical examination day | Case-control | ★★★ | ★★ | ★ | 6 |
Dongxiu et al.14 | 2021 | China | 180/50/50 | FS group: 2.14±0.62 years old; FN group: 2.08±0.59 years old; healthy control: 2.05±0.56 years old | BLOOD | ELISA | FS group and FN group were collected on an empty stomach within 24 h after admission (before treatment), and the healthy control group was collected on an empty stomach in the morning of the physical examination day | Case-control | ★★★★ | ★★ | ★ | 7 |
Tingting et al.15 | 2020 | China | 359/100/100 | All children: 3–60 months | BLOOD | ELISA | FS group and FN group were collected on an empty stomach within 24 h after admission (before treatment), and the healthy control group was collected on an empty stomach in the morning of the physical examination day | Case-control | ★★★★ | ★★ | ★★ | 8 |
Choi et al.16 | 2019 | Korea | 38/20/0 | All children: 3 months–5 years old | BLOOD | ELISA | Patients within 2 h of the time of seizure | Case-control | ★★★★ | ★★ | ★ | 7 |
Marianne et al.17 | 2015 | Egypt | 50/51/25 | FS group: 11.0 (6.0–50.0) months; FN group: 15.0 (6.0–51.0) months; healthy control: 9.0 (6.0–49.0) months | BLOOD | ELISA | Patients within 30 min of the time of seizure | Case-control | ★★★★ | ★★ | ★★ | 8 |
Junhua et al.18 | 2013 | China | 53/33/24 | FS group: 2.34±1.71 years old; FN group: 2.51±1.51 years old; healthy control: 2.22±1.37 years old; | BLOOD | ELISA | FS group and FN group were collected on an empty stomach within 24 h after admission (before treatment), and the healthy control group was collected on an empty stomach in the morning of the physical examination day | Case-control | ★★★ | ★★ | ★ | 6 |
Choi et al.19 | 2011 | Korea | 41/41/7 | All children: 6 months–6 years old | BLOOD | ELISA | Patients within 30 min of the time of seizure | Case-control | ★★★★ | ★★ | ★ | 7 |
Takeshi et al.20 | 2011 | Japan | 18/6/0 | All children: 11 months–10 years old | CSF | ELISA | Not mentioned | Case-control | ★★★ | ★★ | ★ | 6 |
