Table 3 Association between current or baseline value of uric acid and the hazard of kidney failure or death before kidney failure. Results from time-dependent cause-specific Cox models accounting for nonlinear effect uric acid. CKD-REIN cohort, France, 2013–2018.

	Current value of UA*	Model 1 (N = 2344)		Model 2 (N = 1212)		Model 3 (N = 2344)
	Current value of UA*	HR	95% CI	HR	95% CI	HR	95% CI
Kidney failure	3 mg/dl	0.41	0.31–0.54	0.36	0.18–0.69	0.98	0.77–1.25
	5 mg/dl	1		1		1
	7 mg/dl	1.28	1.15–1.43	1.16	0.78–1.72	1.03	0.97–1.09
	9 mg/dl	1.23	1.03–1.46	0.98	0.64–1.51	1.06	0.88–1.28
	11 mg/dl	1.70	1.18–2.47	1.64	1.20–2.24	1.09	0.83–1.42
Death	3 mg/dl	1.80	1.47–2.19	1.43	0.93–2.20	0.92	0.62–1.38
	5 mg/dl	1		1		1
	7 mg/dl	0.88	0.75–1.04	0.92	0.89–0.95	1.11	1.00–1.23
	9 mg/dl	1.25	0.90–1.76	1.23	0.95–1.60	1.22	0.94–1.57
	11 mg/dl	2.30	1.84–2.87	2.23	1.73–2.89	1.23	0.97–1.56

UA, uric acid; HR, hazard ratio; CI, confidence intervals.
Uric acid in mg/dl to µmol/l, × 59.48.
Model 1: Cox model with UA as a continuous time-dependent variable and adjusted for age, sex, CKD stage, primary kidney disease, hypertension, diabetes, cardiovascular disease, dyslipidemia, body mass index, albuminuria, medication adherence, use of renin-angiotensin system inhibitors and urate lowering therapy, all at baseline. HR of death were further adjusted for spironolactone and antiplatelet agents at baseline.
Model 2: Model 1 further adjusted for salt and protein intake at baseline.
Model 3: Cox model with UA as a continuous variable measured only at baseline and adjusted for the same factors as Model 1.
*The listed values of UA are precise current values since uric acid was taken as a continuous time-dependent covariate in the Cox model. HR of 1.70 for example means that a patient with a current value of uric acid of precisely 11 mg/dl had a 70% increased hazard of kidney failure at that time of follow-up compared to a patient with a value of uric acid of precisely 5 mg/dl at the same time.

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