Table 1 α-glucosidase inhibitory activity of 6a–r

From: Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors

Compounds

X

IC50 ± SD (µM)a

6a

Benzyl

153.7 ± 0.9

6b

2-Fluorobenzyl

187.9 ± 2.4

6c

3-Fluorobenzyl

76.7 ± 0.7

6d

4-Fluorobenzyl

80.9 ± 1.1

6e

2-Chlorobenzyl

663.7 ± 1.2

6f

3-Chlorobenzyl

48.2 ± 0.4

6g

4-Chlorobenzyl

96.6 ± 0.1

6h

2-Bromobenzyl

133.5 ± 1.3

6i

3-Bromobenzyl

65.5 ± 2.0

6j

4-Bromobenzyl

28.0 ± 0.6

6k

3,4-Dichlorobenzyl

99. 4 ± 0.7

6l

2-Methylbenzyl

195.7 ± 0.6

6m

3-Methylbenzyl

158.4 ± 2.4

6n

4-Methylbenzyl

116.6 ± 0.5

6o

2,3-Dimethylbenzyl

126.9 ± 0.5

6p

4-Nitrobenzyl

89.2 ± 1.3

6q

4-Methoxybenzyl

67.3 ± 0.8

6r

Ethyl

300.7 ± 2.0

Acarbose

–

750.0 ± 5.0

  1. aData represented in terms of mean ± SD.
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