Table 3 ADMET prediction of the synthesized derivatives as α-glucosidase inhibitors.
Absorption | Distribution | Metabolism | Excretion | Toxicity | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Human Intestinal Absorption (% absorbed) | VDss (logL/Kg) | 2D6 | 3A4 | 1A2 | 2C19 | 2C9 | 2D6 | 3A4 | Total Clearance (log mL/min/kg) | Oral rat acute toxicity (mol/kg) | |
Substrate | Inhibitor | ||||||||||
6a | 84.416 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.051 | 2.44 |
6b | 83.65 | 0.047 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.956 | 2.44 |
6c | 83.65 | 0.047 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.99 | 2.44 |
6d | 83.65 | 0.047 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.006 | 2.44 |
6e | 82.755 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.961 | 2.44 |
6f. | 82.755 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.961 | 2.44 |
6g | 82.755 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.961 | 2.44 |
6h | 82.688 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.047 | 2.44 |
6i | 82.688 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.933 | 2.44 |
6j | 82.688 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 0.896 | 2.44 |
6k | 81.094 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.084 | 2.44 |
6l | 84.214 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.035 | 2.44 |
6m | 84.214 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.035 | 2.44 |
6n | 84.214 | 0.051 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.035 | 2.44 |
6o | 84.011 | 0.054 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.132 | 2.44 |
6p | 82.091 | 0.085 | No | Yes | Yes | Yes | Yes | No | Yes | 0.778 | 2.48 |
6q | 84.413 | 0.049 | No | Yes | Yes | Yes | Yes | Yes | Yes | 1.08 | 2.44 |
6r | 84.011 | 0.043 | Yes | No | Yes | Yes | Yes | Yes | No | 1.037 | 2.42 |
Acarbose | 4.172 | -0.836 | No | No | No | No | No | No | No | 0.428 | 2.45 |
