Table 4 Drug-likeness properties of derivatives.
Compound | MW | Num. rotatable bonds | Num. H-bond acceptors | Num. H-bond donors | Log P |
|---|---|---|---|---|---|
6a | 367.477 | 4 | 3 | 2 | 6.071 |
6b | 385.467 | 4 | 3 | 1 | 6.21 |
6c | 385.467 | 4 | 3 | 1 | 6.21 |
6d | 385.467 | 4 | 3 | 1 | 6.21 |
6e | 401.922 | 4 | 3 | 1 | 6.72 |
6f | 401.922 | 4 | 3 | 1 | 6.72 |
6g | 401.922 | 4 | 3 | 1 | 6.72 |
6h | 446.373 | 4 | 3 | 1 | 6.83 |
6i | 446.373 | 4 | 3 | 1 | 6.83 |
6j | 446.373 | 4 | 3 | 1 | 6.83 |
6k | 436.367 | 4 | 3 | 1 | 7.38 |
6l | 381.504 | 4 | 3 | 1 | 6.38 |
6m | 381.504 | 4 | 3 | 1 | 6.38 |
6n | 381.504 | 4 | 3 | 1 | 6.38 |
6o | 395.53 | 4 | 3 | 1 | 6.69 |
6p | 412.474 | 5 | 5 | 1 | 5.97 |
6q | 397.503 | 4 | 3 | 1 | 6.69 |
6r | 305.406 | 3 | 3 | 1 | 4.89 |
