Table 2 Saliva sACE2 isoform identification in children and adults.
sACE2 isoform type | SARS-CoV-2 RNA− children | SARS-CoV-2 RNA+ children | Convalescent adults | |||||
|---|---|---|---|---|---|---|---|---|
No. (%) | Mean sACE2 level (A) | No. (%) | Mean sACE2 level (B) | No. (%) | Mean sACE2 level (C) | p-value (A–B) | p-value (A–C) | |
Short-length (< 90 kDa) | 179 (86.5) | 0.393 | 60 (96.8) | 0.189 | 253 (93.4) | 0.168 | 0.05 | < 0.001 |
De-glycosylated (75–87 kDa) | 7 (3.4) | 2 (3.2) | 4 (1.5) | |||||
Splicing variant (50–70 kDa) | 106 (51.2) | 24 (38.7) | 90 (33.2) | |||||
Proteolytic product (< 50 kDa) | 66 (31.9) | 34 (54.8) | 159 (58.7) | |||||
Full-length (≥ 90 kDa) | 28 (13.5) | 0.449 | 2 (3.2) | 0.027 | 18 (6.6) | 0.157 | 0.32 | 0.09 |
Highly glycosylated (≥ 175 kDa) | 20 (9.7) | 2 (3.2) | 8 (3.0) | |||||
Partially glycosylated (90–150 kDa) | 8 (3.9) | – | 10 (3.7) | – | ||||
