Figure 4

Complement profiles in COPD lesser decliners behave more similarly to TEPPS than COPD greater decliners. (a) Scores plot from PCA completed using all complement proteins measured in plasma (C1q, C1qBP, C1r, C2, C3d, C3b, C3, C3a, iC3b, C3a des Arg, C4, C4b, C5, C5a, C5-6, C6, C7, C8, C9, Factor B, Factor D, Properdin) of greater decliners (circles), lesser decliners (squares), and a reference group of tobacco-exposed people with preserved spirometry (TEPPS) (diamonds). First two principal components (PCs) capture 33.9% of the variance in the dataset. (b) Comparison of scores on PC1 (one-way ANOVA with Tukey’s post-hoc test; **p<0.01, ***p<0.001).