Table 3 AF risk of BMI according to the age-, sex-, and clinical variable–adjusted model with competing risk of death in the total population.

From: Association of obesity with incident atrial fibrillation in Korea and the United Kingdom

 

Korean NHIS-HealS

U.K. Biobank

P for interaction

sHR (95% CI)

P value

sHR (95% CI)

P value

With BMI as a 1-SD increase

1-SD (2.9 kg/ m2)

 

1-SD (4.8 kg/ m2)

  

 Age, sex-adjusted

1.16 (1.14–1.18)

 < 0.001

1.36 (1.34–1.38)

 < 0.001

 < 0.001

 Adjusted for clinical variables*

1.08 (1.06–1.11)

 < 0.001

1.28 (1.23–1.32)

 < 0.001

 < 0.001

With BMI as a 1 kg/ m2 increase

 Age, sex-adjusted

1.05 (1.05–1.06)

 < 0.001

1.07 (1.07–1.07)

 < 0.001

 < 0.001

 Adjusted for clinical variables*

1.03 (1.02–1.04)

 < 0.001

1.05 (1.05–1.06)

 < 0.001

 < 0.001

With BMI as a categorical variable

 Age, sex-adjusted

  Underweight (< 18.5 kg/ m2)

0.86 (0.73–1.01)

0.063

1.07 (0.86–1.32)

0.566

0.357

  Normal (18.5 to < 25 kg/ m2)

1 (reference)

 

1 (reference)

  

  Overweight (25 to < 30 kg/ m2)

1.19 (1.10–1.28)

 < 0.001

1.18 (1.14–1.21)

 < 0.001

 < 0.001

  Obese (≥ 30 kg/ m2)

1.45 (1.19–1.77)

 < 0.001

1.94 (1.87–2.00)

 < 0.001

 < 0.001

 Adjusted for clinical variables*

  Underweight (< 18.5 kg/ m2)

1.18 (1.01–1.38)

0.043

0.86 (0.48–1.55)

0.619

0.309

  Normal (18.5 to < 25 kg/ m2)

1 (reference)

 

1 (reference)

  

  Overweight (25 to < 30 kg/ m2)

1.15 (1.10–1.21)

 < 0.001

1.10 (1.02–1.19)

0.011

0.001

  Obese (≥ 30 kg/ m2)

1.41 (1.26–1.58)

 < 0.001

1.68 (1.54–1.82)

 < 0.001

0.032

  1. NHIS-HealS National Health Insurance Service’s Health Screening, sHR subdistribution hazard ratio.
  2. *Adjusted for age, sex, and clinical variables including smoking, alcohol use, heart failure, hypertension, diabetes mellitus, ischemic stroke or transient ischemic attack, previous myocardial infarction, hyperthyroidism, hypothyroidism, osteoporosis, dyslipidemia, end stage renal disease or chronic kidney disease, chronic obstructive pulmonary disorder, history liver disease, and history malignant neoplasm.
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