Figure 5
From: DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
DNMT1 deletion, its protein consequence and differential expression profile in human colon cancer. (a) Oncoprint of DNMT1 genetic alterations (deep deletion and gene amplification) in 105 cases of colon cancers. (b) Heatmap of DNMT1 protein expression in 86 cases without DNMT1 deletion in relation to the 8 cases with DNMT1 gene deletion including deep and shallow. Each row represents one patient. *P = 0.017. (c) Protein consequence of the genes enriched in the DNMT1 deleted and undeleted groups shown in volcano plot. (d) Bar graph showing top enriched proteins in the deleted (blue bars) and undeleted (orange bars) groups; all q values < 0.05.
