Figure 5 | Scientific Reports

Figure 5

From: Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome

Figure 5

p-cresol concentration following competition-index assays of C. difficile 630Δerm and E. coli. 630Δerm and E. coli underwent competition-index assays, the bacteria were co-cultured in the presence of p-HPA with and without the test compounds for 14 h to determine how these compounds affected C. difficile’s ability to compete with E. coli. Where samples were available at the end of the co-culture assays HPLC analysis was performed to determine p-cresol concentration. Data represents the means and standard deviations of a minimum of two independent replicates. Regression analysis was carried out using StataSE 17 to determine significant differences in the p-cresol concentration, significant differences are indicated by: **p < 0.01. All graphs were generated in GraphPad Prism 8.

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