Table 2 Diagnostic performance of Truenat & GeneXpert in smear positive and negative specimens with MGIT culture.
From: Expedited diagnosis of pediatric tuberculosis using Truenat MTB-Rif Dx and GeneXpert MTB/RIF
MGIT | MGIT | |||||||
|---|---|---|---|---|---|---|---|---|
Truenat | Pos | Neg | Total | GeneXpert | Pos | Neg | Total | |
AFB smear (+) (n = 47) | Pos | 18 | 13 | 31 | Pos | 24 | 16 | 40 |
Neg | 8 | 8 | 16 | Neg | 2 | 5 | 7 | |
26 | 21 | 47 | 26 | 21 | 47 | |||
Sensitivity | 69.2 (48.2, 85.7) | Sensitivity | 92.3 (74.9, 99.1) | |||||
Specificity | 39.1 (18.1, 61.6) | Specificity | 23.8 (8.22, 47.2) | |||||
Positive predictive value | 58.1 (39.1, 75.5) | Positive predictive value | 60 (43.3, 75.1) | |||||
Negative predictive value | 50 (24.7, 75.3) | Negative predictive value | 71.4 (29, 96.3) | |||||
Positive likelihood ratio | 1.12 (0.73, 1.71) | Positive likelihood ratio | 1.21 (0.93, 1.58) | |||||
Negative likelihood ratio | 0.80 (0.36, 1.79) | Negative likelihood ratio | 0.32 (0.06, 1.5) | |||||
Truenat | MGIT | GeneXpert | MGIT | |||||
|---|---|---|---|---|---|---|---|---|
Pos | Neg | Total | Pos | Neg | Total | |||
AFB smear (−) (n = 565) | Pos | 26 | 54 | 80 | Pos | 18 | 30 | 48 |
Neg | 23 | 462 | 485 | Neg | 31 | 486 | 517 | |
49 | 516 | 565 | 49 | 516 | 565 | |||
Sensitivity | 53.1 (38.3 (67.5) | Sensitivity | 36.7 (23.4, 51.7) | |||||
Specificity | 89.5 (86.6, 92) | Specificity | 94.2 (91.8, 96) | |||||
Positive predictive value | 32.5 (22.4, 43.9) | Positive predictive value | 37.5 (24, 52.6) | |||||
Negative predictive value | 95.3 (93, 97) | Negative predictive value | 94 (91.6, 95.9) | |||||
Positive likelihood ratio | 5.07 (3.52, 7.3) | Positive likelihood ratio | 6.32 (3.81, 10.5) | |||||
Negative likelihood ratio | 0.52 (0.38, 0.7) | Negative likelihood ratio | 0.67 (0.54, 0.83) | |||||
