Table 2 Enriched pathways among the top 1698 differentially expressed genes (DEGs) from the DESeq2 analysis of polyp versus adjacent non-polyp mucosa in the same CRSwNP patient.
KEGG—pathways | Number of hits | Expected score | Adjusted p-value |
|---|---|---|---|
Metabolic pathways | 108 | 66.14 | 0.001 |
Phagosome | 24 | 7.14 | 0.001 |
Complement and coagulation cascades | 16 | 3.65 | 0.002 |
WikiPathways | |||
Microglia pathogen phagocytosis pathway | 16 | 1.67 | 9.97 × 10–07 |
Genes related to primary cilium development (based on CRISPR) | 23 | 5.11 | 2.07 × 10–05 |
TYROBP Causal Network | 14 | 2.87 | 0.003 |
Human Complement System | 16 | 4.07 | 0.006 |
Intraflagellar transport proteins binding to dynein | 9 | 1.30 | 0.010 |
PANTHER—pathways | |||
Inflammation mediated by chemokine and cytokine signaling pathway | 24 | 8.24 | 0.003 |
Reactome—pathways | |||
Neutrophil degranulation | 54 | 21.16 | 1.32 × 10–05 |
Intraflagellar transport | 16 | 2.50 | 9.24 × 10–05 |
Anchoring of the basal body to the plasma membrane | 18 | 4.22 | 0.002 |
Immunoregulatory interactions (Lymphoid and a non-Lymphoid cell) | 17 | 4.48 | 0.009 |
Cell marker/cell types | |||
Esophagus—Ciliated epithelial cell (425) | 162 | 20.01 | 8.53 × 10–78 |
Lung—Ciliated cell (276) | 122 | 12.72 | 1.49 × 10–64 |
Microglial cell (483) | 88 | 21.58 | 6.31 × 10–23 |
Paneth cell (314) | 69 | 13.71 | 3.32 × 10–22 |
CD1C-CD141- dendritic cell (314) | 55 | 14.07 | 1.93 × 10–13 |
Monocyte (846) | 96 | 37.32 | 3.33 × 10–13 |
SLC16A7 + cell (988) | 105 | 43.42 | 5.41 × 10–13 |
Macrophage (105) | 25 | 4.48 | 1.42 × 10–08 |
Sertoli cell (457) | 56 | 21.00 | 4.67 × 10–08 |
Eosinophil (54) | 16 | 2.24 | 1.34 × 10–06 |
