Table 4 Enriched pathways among the top 1494 differentially expressed genes (DEGs) from the DESeq2 analysis of healthy mucosa from control vs non-polyp mucosa from patient with CRSwNP.
KEGG—pathways | Number of hits | Expected score | Adjusted p-value |
|---|---|---|---|
Herpes simplex virus 1 infection (Genes pcorr < 0.05, n = 3863) | 103 | 29.69 | 4.33 × 10–19 |
Herpes simplex virus 1 infection (Genes pcorr < 0.01, n = 1494) | 44 | 11.48 | 1.46 × 10–09 |
Protein processing in endoplasmic reticulum | 27 | 6.11 | 1.17 × 10–06 |
Cell cycle | 21 | 4.72 | 4.50 × 10–05 |
Systemic lupus erythematosus | 20 | 5.24 | 5.72 × 10–04 |
WikiPathways | |||
Cell Cycle | 21 | 4.55 | 8.88 × 10–05 |
Circadian rhythm related genes | 23 | 7.58 | 0.005 |
PANTHER—pathways | |||
N/A | |||
Reactome—pathways | |||
Generic Transcription Pathway | 36 | 7.02 | 1.86 × 10–10 |
HATs acetylate histones | 29 | 5.85 | 4.94 × 10–08 |
Estrogen-dependent gene expression | 28 | 5.68 | 7.87 × 10–08 |
Meiotic recombination | 22 | 3.55 | 1.57 × 10–07 |
Cell marker/cell types | |||
Natural killer T (NKT) cell (4557) | 377 | 171.92 | 2.35 × 10–45 |
Meiotic prophase fetal germ cell (1038) | 86 | 41.12 | 2.50 × 10–07 |
Neural progenitor cell (175) | 27 | 7.02 | 4.24 × 10–06 |
SLC16A7 + cell (988) | 72 | 36.09 | 1.69 × 10–05 |
Mitotic arrest phase fetal germ cell (951) | 69 | 37.17 | 2.69 × 10–04 |
Naive CD8 + T cell (93) | 14 | 3.47 | 0.003 |
