Figure 2 | Scientific Reports

Figure 2

From: The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study

Figure 2

Joint associations of individual-level socio-economic status (SES) and adjusted residual leucocyte telomere length (LTL) with incident dementia and Alzheimer’s disease among UK Biobank participants. Analyses were performed based on data of 331,066 participants for (a) incident dementia and (b) incident Alzheimer’s disease. Models included age, sex, ethnicity, healthy lifestyle score, social activities, hearing difficulty, abdominal obesity, frailty index, urbanicity and neighbourhood deprivation. Residual of LTL, adjusted for chronological age, C-reactive protein and co-morbidities was defined as biological age in the study. The vertical bars indicate the hazard ratio, while the whiskers indicate the corresponding 95% confidence interval (CI). The asterisks represent statistically significant (two-sided p < 0.05) point estimates. Relative excess risk due to interaction (RERI) was used to examine additive interaction between SES (low SES versus high SES) and LTL (short LTL versus long LTL). See Supplementary Table S7 for detailed estimates, the corresponding 95% CI and calculations of RERI.

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