Table 2 Associations of individual-level socioeconomic status (SES) with risks of incident dementia and Alzheimer’s disease among UK Biobank participants.

From: The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study

 

Total

Individual-level SES stratad

p trend

High

Medium

Low

N/Events

HR (95% CI)

HR (95% CI)

HR (95% CI)

Incident dementia

 N/Events

331,066/3,313

111,525/350

138,373/1,280

81,168/1,683

 

 Model 1a

 

1–Ref

1.66 (1.47–1.88)

3.02 (2.68–3.40)

 < 0.001

 Model 2b

 

1–Ref

1.60 (1.42–1.80)

2.59 (2.29–2.92)

 < 0.001

 Model 3c

 

1–Ref

1.59 (1.41–1.80)

2.58 (2.28–2.91)

 < 0.001

Incident Alzheimer’s disease

 N/Events

331,066/1,423

111,525/143

138,373/528

81,168/752

 

 Model 1a

 

1–Ref

1.60 (1.32–1.93)

3.06 (2.54–3.68)

 < 0.001

 Model 2b

 

1–Ref

1.55 (1.28–1.87)

2.70 (2.23–3.25)

 < 0.001

 Model 3c

 

1–Ref

1.54 (1.28–1.86)

2.68 (2.22–3.24)

 < 0.001

  1. aModel 1 included age and sex.
  2. bModel 2 included variables in Model 1 and additionally adjusted for ethnicity, healthy lifestyle score, social activities, hearing difficulty, abdominal obesity, frailty index, urbanicity and neighbourhood deprivation.
  3. cModel 3 included variables in Model 2 and additionally adjusted for biological age (measured as residual of leucocyte telomere length, LTL, adjusted for chronological age, C-reactive protein and co-morbidities).
  4. leucocyte telomere length, LTL).
  5. dIndividual-level SES is derived from latent class analysis by using participants’ reported data on highest education attainment, employment status and household income.
  6. CI Confidence interval; HR Hazard ratio; N Number of participants.