Figure 4

Principal coordinate analysis (PCoA) of the bacterial community composition using: (A) prevalence interval for microbiome evaluation (PIME) filtered data to remove noise from taxa not prevalent within sample groups; (B) using all microbial taxa (ASV) from centered-log ratio normalization; and the latter (C) at the phylum, and (D) genus taxonomy levels. Statistical differences for permutational multivariate analysis of variance (PERMANOVA) were declared at P ≤ 0.05.