Figure 2 | Scientific Reports

Figure 2

From: Chronic Mycobacterium avium infection differentially affects the cytokine expression profile of three mouse strains, but has no effect on behavior

Figure 2

Chronic infection with M. avium induces a distinct cytokine/inflammatory molecules profile in the hippocampus and spleen of the different mouse strains. mRNA expression levels for the anti-inflammatory cytokines Il-10 and Tgf-β, pro-inflammatory cytokines Ifn-γ, Tnf, Il-1β and Il-6, and the inflammatory molecules Ido and iNos were measured in the spleen (A–C) and hippocampus (D–F) of Balb/c (A and D), C57BL/6 (B and E) and CD1 (C and F) mice at 4wpi and non-infected. The mRNA expression levels were normalized using 3 reference genes Hprt, Gapdh and 18S. Each bar represents the mean of the fold change of the ratio infected/non-infected + SEM of 6–8 mice per strain from 1 of 2 independent experiments with similar results. *p < 0.05.

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