Table 2 Burden of self-reported acute and persistent symptoms stratified by age and sex.

From: Sex and age affect acute and persisting COVID-19 illness

 

Total (N = 97)

Younger adults (< 60 y.o.)

Older adults (60 + y.o.)

P value

Female (N = 48)

Male (N = 23)

Female (N = 14)

Male (N = 12)

Age

Sex

Age × Sex

Acute symptoms, median (Min–Max)

 Total symptoms

9 (0–19)

11 (0–16)

7 (0–17)

10 (0–19)

6 (4–9)

.7

.001

.3

Persistent symptoms, median (Min–Max)

 Time from acute symptom onset to clinic visit, months

9 (3–21)

9 (3–18)

9 (3–21)

9 (5–20)

8 (4–18)

.6

.06

.05

 Physical symptoms

1 (0–6)

2 (0–6)

1 (0–4)

1 (0–4)

1 (0–3)

.07

.5

.8

 Short term memory symptoms

3 (0–4)

3 (0–4)

3 (0–4)

3 (0–4)

2 (0–3)

.2

.1

1

 Executive function symptoms

3 (0–6)

3 (0–5)

3 (0–5)

3.5 (2–6)

2.5 (0–4)

.8

.1

.4

 Language symptoms

2 (0–5)

2 (0–5)

2 (0–4)

2 (0–5)

2 (0–4)

.7

.3

1

 Visuospatial symptoms

0 (0–2)

0 (0–2)

0 (0)

0 (0–1)

0 (0)

NA

NA

NA

 Personality symptoms

0 (0–3)

0 (0–3)

0 (0–2)

0 (0–3)

0 (0–1)

NA

NA

NA

 Neuropsychiatric symptoms

5 (0–9)

5 (0–8)

4 (0–9)

4 (1–9)

4 (0–8)

.9

.3

.9

 Neurological symptoms

3 (0–11)

3 (1–8)

2 (0–7)

3 (0–11)

2 (0–7)

.8

.1

.9

 Total symptoms

18 (2–37)

20 (2–33)

15 (2–25)

16 (7–37)

13.5 (3–25)

.08

 < .001

.4

  1. Data presented as Median (Min–Max). Symptom burden is quantified as number of self-reported symptoms per person. Negative binomial regression with log link to control for overdispersion adjusted for ICU admission status, combined past medical history, and abnormal brain MRI findings was used. “NA” designation was used where low per-group patient number did not allow for statistical comparisons. NA, not applicable. Significant values are in [bold].