Table 1 FRET analysis of G-quadruplex melting temperatures in the presence of tested compounds at a concentration of 2 μM.

From: Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors

Compound

Tm (°C)

ΔTm (°C)

3

61 ± 0.1

10

6

65 ± 0.1

14

12

79 ± 0.2

28

14

64 ± 0.2

13

15

70 ± 1.0

19

PDS

93 ± 13

42

PBS

51 ± 0.1

0

  1. PDS (pyridostatin)—positive control, PBS (buffer)—negative control. The ΔTm was calculated by subtracting the average Tm of PBS (control) from average Tm for each compound. The Tm results were averaged from three independent experiments, depicted as mean and standard error.
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