Figure 6

Matrix heat plot of 79 × 13 drugs versus targets among nociceptors involved in pain triggered by mechanical stimuli (Table 2). Shown are approved and/or investigational drugs that were queried from the DrugBank database along with their targets (https://go.drugbank.com⁴⁴). Marginal statistics (sums) are shown as bar graphs indicating row and column sums of interactions per drug and target, respectively. The figure was created using the R software package (version 4.2.2 for Linux; https://CRAN.R-project.org/ (R Development Core Team, 2008)) and the R library "ComplexHeatmap" (https://bioconductor.org/packages/release/bioc/html/ComplexHeatmap.html⁵⁸).