Table 4 Diagnostic test characteristic of TET3, FIB-4 index and multivariable model in detecting liver fibrosis and cirrhosis.

From: TET3 as a non-invasive screening tool for the detection of fibrosis in patients with chronic liver disease

Model

Fibrosis

Cirrhosis

AUROC(95%CI)

P value

Cut-point

NPV

PPV

AUROC(95%CI)

Cut-point

P value

NPV

PPV

TET3(ng/mL)

0.863(0.804–0.909)

 < 0.0001

194.41

71.80

98.60

0.916(0.860–0.955)

201.62

 < 0.0001

87.90

100

FIB-4 index

0.813(0.749–0.867)

 < 0.0001

1.19

66.00

86.80

0.957(0.911–0.983)

1.84

 < 0.0001

90.20

91.40

TET3 + FIB-4 index

0.943(0.899- 0.972)

 < 0.0001

0.44

83.10

93.50

0.990(0.958–0.999)

0.52

 < 0.0001

96.40

100

  1. NPV: Cut-point was derived from the Youden’s index, NPV: Negative predictive value, PPV: Positive predictive value.
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