Table 1 Baseline characteristics.
Variables | All patients | No event | ADR or death within 60 days | p value |
|---|---|---|---|---|
(n = 632) | (n = 364) | (n = 268) | ||
Age > 85 years | 336 (53.2) | 182 (50.0) | 154 (57.5) | 0.063 |
Female | 251 (39.7) | 147 (40.4) | 104 (38.8) | 0.689 |
BMI < 18.5 m2/kg | 332 (52.5) | 180 (49.5) | 152 (56.7) | 0.071 |
Polypharmacya | 150 (23.7) | 87 (23.9) | 63 (23.5) | 0.908 |
Immunosuppressantsb | 25 (4.0) | 14 (3.8) | 11 (4.1) | 0.869 |
ADL, dependent | 468 (74.1) | 241 (66.2) | 227 (84.7) | < 0.001 |
Smoking history | 267 (42.2) | 156 (42.9) | 111 (41.4) | 0.717 |
Disease status | ||||
Cavitation on chest X-ray | 182 (28.8) | 100 (27.5) | 82 (30.6) | 0.391 |
Extrapulmonary TB and/or extensive disease | 267 (42.2) | 132 (36.3) | 135 (50.4) | < 0.001 |
Sputum smear ≥ 2 + | 235 (37.2) | 129 (35.4) | 106 (39.6) | 0.290 |
Respiratory failure | 166 (26.3) | 65 (17.9) | 101 (37.7) | < 0.001 |
Comorbidities | ||||
At least 1 comorbidity | 472 (74.7) | 256 (70.3) | 216 (80.6) | 0.003 |
Chronic lung diseases | 132 (20.9) | 68 (18.7) | 64 (23.9) | 0.112 |
Chronic heart diseases | 170 (26.9) | 91 (25.0) | 79 (29.5) | 0.210 |
Chronic liver diseases | 21 (3.3) | 12 (3.3) | 9 (3.4) | 0.966 |
Chronic renal diseases | 76 (12.0) | 45 (12.4) | 31 (11.6) | 0.761 |
Neurological disorders | 216 (34.2) | 125 (34.3) | 91 (34.0) | 0.920 |
Active malignancy | 59 (9.3) | 30 (8.2) | 29 (10.8) | 0.271 |
Diabetes mellitus | 148 (23.4) | 84 (23.1) | 64 (23.9) | 0.814 |
Autoimmune diseases | 32 (5.1) | 20 (5.5) | 12 (4.5) | 0.564 |
HIV positive | 0 (0) | 0 (0) | 0 (0) | – |
Laboratory findings | ||||
Albumin < 2.5 g/dL | 195 (30.9) | 77 (21.2) | 118 (44.0) | < 0.001 |
Abnormal AST and/or ALTc | 160 (25.3) | 84 (23.1) | 76 (28.4) | 0.131 |
Renal failure (CCr < 30 mL/min) | 202 (32.0) | 105 (28.8) | 97 (36.2) | 0.050 |
