Table 5 Receiver operating characteristic (ROC) curve analysis of serum lipid levels and TG/HDL-C ratio for diagnosis of severe DILI.

From: Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

Severity of DILI

Cho

TG

HDL-C

LDL-C

FFA

TG/HDL-C

AUC

0.52

0.81

0.84

0.50

0.67

0.89

Sensitivity

0.27

0.82

0.85

0.19

0.66

0.79

1 − Specificity

0.16

0.25

0.19

0.05

0.32

0.11

Youden index

0.11

0.57

0.66

0.14

0.34

0.69

Cut-off value

5.72 mmol/L

1.80 mmol/L

0.82 mmol/L

4.18 mmol/L

71.00 µmol/L

2.35

p

0.62

 < 0.01

 < 0.01

0.91

 < 0.01

 < 0.01

  1. TG triglyceride, Cho cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, FFA free fatty acid, DILI drug induced liver injury, AUC the area under the receiver-operating characteristic curve.
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