Table 7 Liver functions in DILI and acute hepatitis B group.

From: Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

Variable

DILI

HBV

DILI injury classes

DILI medication classes

Hepatocellular liver injury

Cholestatic liver injury

Mixed liver injury

Chinese herbal medicines

Both

Western medicines

ALT(U/L)

384.23 ± 375.12

431.04 ± 631.03

589.52 ± 418.53ac

139.21 ± 119.55b

653.09 ± 245.58a

435.93 ± 381.82a'

401 ± 398.75a'b'

296.62 ± 341.72b'

AST(U/L)

224.05 ± 236.89

253.48 ± 467.91

309.88 ± 275.95ac

110.52 ± 113.39b

386.57 ± 243a

256.81 ± 255.17a'

200 ± 192.63a'b'

183.53 ± 219.25b'

GGT(U/L)

285.24 ± 266.36##

154.74 ± 129.09

216.35 ± 201.21b

337.48 ± 299.72a

330.52 ± 287.1ab

260.23 ± 226.6

310.91 ± 231.32

312.99 ± 329.92

AKP (U/L)

181.14 ± 124.27##

123.35 ± 52.46

131.95 ± 64b

219.34 ± 156.35a

209.52 ± 67.72ac

163.2 ± 77.2

179.59 ± 111.28

209.7 ± 175.04

TBIL (µmol/L)

93.48 ± 113.49##

58.64 ± 76.21

75.87 ± 96.12b

100.14 ± 120.97ab

135.35 ± 133.68a

109.78 ± 118.68a'

85.73 ± 94.48a'b'

71.5 ± 109.99b'

DBIL (µmol/L)

67.54 ± 84.33##

42.31 ± 92.03

54.37 ± 71.29b

72.35 ± 89.74ab

99.64 ± 99.96a

78.61 ± 86.17a'

62.07 ± 72.22ab'

52.71 ± 84.8b'

PT-INR

1.08 ± 0.15##

1.21 ± 0.26

1.11 ± 0.16

1.05 ± 0.14

1.12 ± 0.15

1.1 ± 0.14a'

1.11 ± 0.23a'b'

1.05 ± 0.12b'

  1. ALT aminotransferase, AST Aspartate transaminase, GGT gamma-glutamyl transferase, AKP alkaline phosphatase, TBIL total bilirubin, DBIL direct bilirubin, PT-INR International normalized ratio of prothrombin time.
  2. #P ≤ 0.05; ##P ≤ 0.01. abc: significant difference (P ≤ 0.05) was shown in different DILI injury classes. a’b’c’: significant difference (P ≤ 0.05) was shown in different DILI medication classes.