Table 7 Liver functions in DILI and acute hepatitis B group.
From: Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury
Variable | DILI | HBV | DILI injury classes | DILI medication classes | ||||
---|---|---|---|---|---|---|---|---|
Hepatocellular liver injury | Cholestatic liver injury | Mixed liver injury | Chinese herbal medicines | Both | Western medicines | |||
ALT(U/L) | 384.23 ± 375.12 | 431.04 ± 631.03 | 589.52 ± 418.53ac | 139.21 ± 119.55b | 653.09 ± 245.58a | 435.93 ± 381.82a' | 401 ± 398.75a'b' | 296.62 ± 341.72b' |
AST(U/L) | 224.05 ± 236.89 | 253.48 ± 467.91 | 309.88 ± 275.95ac | 110.52 ± 113.39b | 386.57 ± 243a | 256.81 ± 255.17a' | 200 ± 192.63a'b' | 183.53 ± 219.25b' |
GGT(U/L) | 285.24 ± 266.36## | 154.74 ± 129.09 | 216.35 ± 201.21b | 337.48 ± 299.72a | 330.52 ± 287.1ab | 260.23 ± 226.6 | 310.91 ± 231.32 | 312.99 ± 329.92 |
AKP (U/L) | 181.14 ± 124.27## | 123.35 ± 52.46 | 131.95 ± 64b | 219.34 ± 156.35a | 209.52 ± 67.72ac | 163.2 ± 77.2 | 179.59 ± 111.28 | 209.7 ± 175.04 |
TBIL (µmol/L) | 93.48 ± 113.49## | 58.64 ± 76.21 | 75.87 ± 96.12b | 100.14 ± 120.97ab | 135.35 ± 133.68a | 109.78 ± 118.68a' | 85.73 ± 94.48a'b' | 71.5 ± 109.99b' |
DBIL (µmol/L) | 67.54 ± 84.33## | 42.31 ± 92.03 | 54.37 ± 71.29b | 72.35 ± 89.74ab | 99.64 ± 99.96a | 78.61 ± 86.17a' | 62.07 ± 72.22ab' | 52.71 ± 84.8b' |
PT-INR | 1.08 ± 0.15## | 1.21 ± 0.26 | 1.11 ± 0.16 | 1.05 ± 0.14 | 1.12 ± 0.15 | 1.1 ± 0.14a' | 1.11 ± 0.23a'b' | 1.05 ± 0.12b' |