Figure 5

Protein kinase families and protein kinases regulated by activation of β-ARs. (A) Left: distribution of regulated kinases within each group: CMGC (named after CDK, MAPK, GSK3 and CLK group of protein kinases), STE (named after homologues sterile yeast kinases), AGC (named after Protein kinase A, G and C), TK (tyrosine kinases) CAMK (Calcium/calmodulin protein kinases). Right: predicted effect of β-AR activation on protein kinase activity. (B) Top: charts show protein kinases and protein kinase families with increases (left) and decreased (right) in protein kinase activity induced by β-AR. Bottom: predicted kinases for phosphorylation sites regulated by β-AR activation based on flanking amino acid sequence analysis.