Figure 6 | Scientific Reports

Figure 6

From: Functional and phosphoproteomic analysis of β-adrenergic receptor signaling at excitatory synapses in the CA1 region of the ventral hippocampus

Figure 6

Increases in protein phosphorylation within the PSD protein interaction network induced by β-AR activation (A) and LTP induction (B). Results shown in (B) are from Li et al.39. Scale bars indicate number of regulated phosphorylation sites per protein. The number of phosphorylation sites regulated by β-AR per individual protein was lower than that seen following LTP induction (note difference in scalebars). The PSD protein interaction network was constructed using interactomes of different components of the PSD including Dlg4, Dlgap1, Shank3, Homer1, Syngap1, Agap2, Tsc1, Kalirin, Cnksr2, Tnik, Fmr1, Cyfip1, Cyfip2, Mycbp2, and Nckap1. (C) Sites within the PSD PIN regulated by only β-AR activation, only following the induction of LTP, or co-regulated by both activation of β-ARs and LTP induction.

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