Table 1 Characteristics of patients included and excluded in proteomic analysis. p-values represent a comparison of differences between included middle-aged and older subjects.
Characteristic | Included | Excluded | |||||
|---|---|---|---|---|---|---|---|
Full sample (N = 76) | Older (N = 42) | Middle-aged (N = 34) | P-value | Full sample (N = 124) | Older (N = 58) | Middle-aged (N = 66) | |
Age, years | 68 ± 11 | 77 ± 4 | 56 ± 3 | 0.000 | 64 ± 13 | 77 ± 4 | 54 ± 5 |
Weight, kg | 82.5 ± 16.4 | 81.1 ± 14.6 | 84.2 ± 18.4 | 0.419 | 89.7 ± 22.0 | 85.8 ± 17.8 | 93.4 ± 24.9 |
Body Mass Index, kg/m2 | 29.4 ± 4.7 | 29.0 ± 4.2 | 29.7 ± 5.2 | 0.673 | 30.9 ± 6.1 | 30.5 ± 5.4 | 31.2 ± 6.1 |
Female, n (%) | 41 (53.9) | 21 (50.0) | 20 (58.8) | 0.443 | 56 (45.2) | 27 (46.6) | 28 (42.4) |
Race, n (%) | 0.199 | ||||||
White | 71 (93.4) | 41 (97.6) | 30 (88.2) | 112 (90.3) | 52 (89.6) | 60 (91.0) | |
African American | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (4.0) | 3 (5.2) | 2 (3.0) | |
Asian | 1 (1.3) | 0 (0.0) | 1 (2.9) | 1 (0.8) | 0 (0.0) | 1 (1.5) | |
American Indian or Alaska Native | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 0 (0.0) | 1 (1.5) | |
Other/unknown | 4 (5.3) | 1 (2.4) | 3 (8.8) | 5 (4.0) | 3 (5.2) | 2 (3.0) | |
Ethnicity, n (%) | 0.211 | ||||||
Hispanic | 4 (5.3) | 1 (2.4) | 3 (8.8) | 1 (0.8) | 1 (1.7) | 0 (0.0) | |
Non-Hispanic | 72 (94.7) | 41 (97.6) | 31 (91.2) | 123 (99.2) | 57 (98.3) | 66 (100.0) | |
Education, n (%) | 0.210 | ||||||
High school degree | 32 (42.1) | 15 (35.7) | 17 (50.0) | 42 (33.9) | 22 (37.9) | 20 (30.3) | |
College degree or higher | 44 (57.9) | 27 (64.3) | 17 (50.0) | 66 (53.2) | 29 (50.0) | 37 (56.0) | |
Did not respond | 0 (0.0) | 0 (0.0) | 0 (0.0) | 16 (12.9) | 7 (12.1) | 9 (13.6) | |
ASA physical status, n (%) | 0.000 | ||||||
< 3 | 19 (25.0) | 5 (11.9) | 14 (41.2) | 25 (20.2) | 3 (5.2) | 22 (33.3) | |
≥ 3 | 49 (64.5) | 35 (83.3) | 14 (41.2) | 88 (71.0) | 50 (86.2) | 38 (57.6) | |
Not available | 8 (10.5) | 2 (4.8) | 6 (17.6) | 11 (8.8) | 5 (8.6) | 6 (9.1) | |
MiniCog, n (%) | 0.091 | ||||||
≤ 2 | 10 (13.2) | 8 (19.0) | 2 (5.9) | 16 (12.9) | 11 (19.0) | 5 (7.6) | |
≥ 3 | 66 (86.8) | 34 (81.0) | 32 (94.1) | 102 (82.2) | 44 (75.9) | 58 (87.9) | |
Not available | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (4.8) | 3 (5.2) | 3 (4.5) | |
Verbal fluency, n (%) | 0.163 | ||||||
≤ 16 | 19 (25.0) | 13 (31.0) | 6 (17.6) | 45 (36.3) | 31 (53.4) | 14 (21.2) | |
≥ 17 | 56 (73.7) | 28 (66.6) | 28 (82.4) | 78 (62.9) | 27 (46.6) | 51 (77.2) | |
Not available | 1 (1.3) | 1 (2.4) | 0 (0.0) | 1 (0.8) | 0 (0.0) | 1 (1.5) | |
FRAIL, n (%) | 0.371 | ||||||
Robust | 21 (27.6) | 9 (21.4) | 12 (35.3) | 35 (28.2) | 9 (15.5) | 26 (39.4) | |
Pre-frail | 42 (55.3) | 24 (57.1) | 18 (52.9) | 60 (48.4) | 31 (53.4) | 29 (43.9) | |
Frail | 12 (15.8) | 8 (19.0) | 4 (11.8) | 20 (16.1) | 15 (25.9) | 5 (7.6) | |
Not available | 1 (1.3) | 1 (2.4) | 0 (0.0) | 9 (7.3) | 3 (5.2) | 6 (9.1) | |
Invasiveness, n (%) | 0.008 | ||||||
Tier 1 or 2 | 48 (63.2) | 21 (50.0) | 27 (79.4) | 77 (62.1) | 32 (55.1) | 45 (68.2) | |
Tier 3 or 4 | 28 (36.8) | 21 (50.0) | 7 (20.6) | 46 (37.1) | 25 (43.1) | 21 (31.8) | |
Not available | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 (1.7) | 0 (0.0) | |
Surgery duration, min | 170.8 ± 90.1 | 164.7 ± 73.0 | 177.3 ± 108.9 | 0.549 | 185.5 ± 147.8 | 168.5 ± 104.0 | 199.0 ± 174.6 |
LOS, days | 0.028 | ||||||
Median (Q1, Q3) | 4 (2, 5) | 4 (3, 6) | 2 (2, 4) | 3 (2, 4) | 4 (2, 5) | 2 (2, 4) | |
6-month mortality | 0 | 0 | 0 | 0 | 0 | 0 | |
Postoperative Delirium, n (%) | 22 (28.9) | 14 (33.3) | 8 (23.5) | 0.349 | 12 (10.8) | 6 (12.0) | 6 (9.8) |
