Figure 6 | Scientific Reports

Figure 6

From: Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region

Figure 6

CBD treatments decrease density of the microglial marker TMEM119 within song regions of lesioned hemispheres. (aa-af), TMEM119 immunofluorescence marks microglia, in which a high density of fluorescence is present in vehicle-treated HVC, RA and Area X. Lower TMEM119 staining is evident in the CBD treated group. (ag-al), Merge images of TMEM119 and Hoechst-stained nuclei. (b) TMEM119 density expressed as TMEM119 mean grey value relative Hoechst staining as percentage of the unlesioned hemisphere. Within HVC, RA and Area X, TMEM119 densities were significantly lower in CBD-treated animals relative to vehicle controls. Group differences were determined using mixed-models ANOVA followed by Sidak corrected post-hoc comparisons for n = 4 per group.

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