Figure 8 | Scientific Reports

Figure 8

From: Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region

Figure 8

CBD treatments protect glutamatergic synaptic densities from lesion-related losses within RA. (a–t) Representative confocal images of immunofluorescence illustrating synaptic density in four groups: VEH Unleisoned (a–e), CBD Unlesioned (f–j), VEH Lesioned (k–o), and CBD Lesioned (p–t). Stain is divided into columns with Hoechst, PSD95 (postsynaptic marker), and VGLUT2 (presynaptic marker) respectfully. Column four is a merge of the two stains and column 5 shows a mask of the colocalized puncta of PSD95 and VGLUT2. The synapse masks show that relative to VEH controls CBD groups have significantly higher glutamatergic synapse densities 24 h postlesions.

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