Figure 9 | Scientific Reports

Figure 9

From: Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region

Figure 9

CBD treatments protect glutamatergic synaptic densities from lesion-related losses within Area X. A-T, Representative confocal images of immunofluorescence illustrating synaptic density in four groups: VEH Unleisoned (a–e), CBD Unlesioned (f–j), VEH Lesioned (k–o), and CBD Lesioned (p–t). Stain is divided into columns with Hoechst, PSD95 (postsynaptic marker), and VGLUT2 (presynaptic marker) respectfully. Column 4 is a merge of the two stains and column 5 shows a mask of the colocalized puncta of PSD95 and VGLUT2. The synapse masks show that relative to VEH controls CBD groups have significantly higher glutamatergic synapse densities 24 h post-lesions.

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