Figure 1

Linear regression between absolute discrimination indices quantified by NORT and retinal layer thickness measured by OCT in 4-month-old C57BL/6J mice at baseline, 6 months and 9 months of age. Relationships were considered significant if the gradient of regression lines were significantly non-zero. Only INL and ONL data demonstrated significant relationships. (a) There is a non-significant positive linear relationship between absolute NFL-GCL-IPL thickness and discrimination index (p = 0.3826). (b) There is a significant positive linear relationship between INL thickness and discrimination index (p = 0.0020). (c) There is a significant positive linear relationship between ONL thickness and discrimination index (p = 0.0264). (d) There is a non-significant negative relationship between TR thickness and discrimination index (p = 0.5785). NFL-GCL-IPL nerve fibre layer-ganglion cell layer-inner plexiform layer, INL inner nuclear layer, ONL outer nuclear layer, TR total retina thickness. NFL-GCL-IPL, INL and ONL positively correlated with discrimination indices, whereas TR was negatively correlated with discrimination indices. Data points represent one mouse for each eye at a single point in time. Regression line equations and r² values for each dataset are presented in Supplementary Table S1.