Table 5 Distribution of addiction systems among CTX-M-encoding transmissible plasmids that were successfully mobilised to recipient E. colia.

From: Characterization of plasmids carrying blaCTX-M genes among extra-intestinal Escherichia coli clinical isolates in Ethiopia

CTX-M with other β-lactamases

n

Plasmids Addiction systems

pmeK

ccdB

vagCD

hok-sok

pndC

srnBC

totalb

Meanc

CTX-M-15

51

33

28

15

2

17

28

123

2.4

Only CTX-M-15

5

3

3

1

0

2

3

12

2.4

 + TEM-1

19

7

5

0

0

7

4

23

1.3

 + OXA-1

9

9

9

6

1

3

9

37

4.1

 + TEM, OXA-1

18

14

11

8

1

5

12

51

2.8

Other group-1 CTX-Ms

17

10

6

3

1

3

9

32

1.9

Only CTX-M (other)

5

2

2

2

0

1

2

9

1.8

 + TEM

3

1

1

0

0

2

1

5

1.7

 + OXA-1

3

3

1

1

0

0

3

8

2.7

 + TEM, OXA-1

6

4

2

0

1

0

3

10

1.7

Group 9 CTX-M

7

4

5

3

1

3

5

21

3.0

CTX-M14 + TEM

1

0

0

0

0

0

0

0

0

CTX-M-27

3

2

2

1

1

2

2

10

3.3

 + OXA-1

1

1

1

0

0

0

1

3

3.0

 + TEM, OXA-1

2

1

2

2

0

1

2

8

4.0

Total

75

47

39

21

4

23

42

176

2.3

  1. aMobilisation of transmissible plasmids into E. coli J53 AziR was by conjugation and into HB101 was by chemical transformation.
  2. bRefers to the total number of isolates that had an identifiable addiction system encoded on a plasmid with defined CTX-M producing genes alone or in combination with alternative β-lactamase-encoding genes (non-ESBLs genes).
  3. cRefers to the average number of addiction systems encoded on a plasmid with defined β-lactamase-encoding genes; calculated as ‘total’ number of identified addiction systems divided by ‘n’ number of isolates containing a plasmid(s) with stated β-lactamase-encoding gene.
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