Table 2 Plasma nicotine pharmacokinetic parameters across Vuse Solo variants.
PK parameters assessed | Original (N = 28) | Mint (N = 34) | Tropical (N = 28) | Fusion (N = 28) |
---|---|---|---|---|
Cmax (ng/mL) (95% CI) | 6.91 (5.49–8.70) | 6.53 (5.26–8.10) | 8.21 (6.87–9.81) | 6.67 (5.20–8.56) |
AUCnic0–15 (ng min/mL) (95% CI) | 56.19 (42.85–73.69) | 63.36 (50.64–79.27) | 76.28 (63.38–91.81) | 56.15 (43.81–71.97) |
AUCnic0–60 (ng min/mL) (95% CI) | 223.79 (180.13–278.03) | 215.37 (175.92–263.68) | 263.52 (218.92–317.20) | 206.87 (156.70–273.10) |
Tmax* (min) (range) | 11.00 (5.0–60.0) | 11.00 (3.0–30.0) | 11.00 (3.0–30.4) | 11.00 (3.0–30.0) |