Table 2 Plasma nicotine pharmacokinetic parameters across Vuse Solo variants.

From: Part two: an unblinded, parallel, randomized study to assess nicotine pharmacokinetics of four Vuse Solo ENDS flavors in smokers

PK parameters assessed

Original (N = 28)

Mint (N = 34)

Tropical (N = 28)

Fusion (N = 28)

Cmax (ng/mL) (95% CI)

6.91 (5.49–8.70)

6.53 (5.26–8.10)

8.21 (6.87–9.81)

6.67 (5.20–8.56)

AUCnic0–15 (ng min/mL) (95% CI)

56.19 (42.85–73.69)

63.36 (50.64–79.27)

76.28 (63.38–91.81)

56.15 (43.81–71.97)

AUCnic0–60 (ng min/mL) (95% CI)

223.79 (180.13–278.03)

215.37 (175.92–263.68)

263.52 (218.92–317.20)

206.87 (156.70–273.10)

Tmax* (min) (range)

11.00 (5.0–60.0)

11.00 (3.0–30.0)

11.00 (3.0–30.4)

11.00 (3.0–30.0)

  1. PK Parameters presented in this table are baseline-adjusted geometric mean values except for Tmax.
  2. Subjects with Cmax < 1.0 ng/mL were excluded from this analysis.
  3. CI confidence interval, Cmax maximum nicotine concentration, AUCnic0–15 area under the curve for nicotine exposure over 15 min, AUCnic0–60 area under the curve for nicotine exposure over 60 min, Tmax time to maximum nicotine concentration.
  4. *Tmax reported as median value, followed by the range for minimum and maximum.