Figure 1 | Scientific Reports

Figure 1

From: Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain

Figure 1

Immunohistochemistry results of BCL11B in the mouse brains isolated 7 days after MCAO or Sham surgery. (A) Representative immunofluorescent images of BCL11B (green) expression in neocortex, striatum, and hippocampus of MCAO and Sham experimental groups. The images were taken from the ipsilateral brain hemisphere. Regions of interest displayed on immunofluorescent images are marked with the red square on the representative MR image of the mouse brain. (B–D) Results of the integrated optical density measurements of BCL11B fluorescent signal in neocortex (B), striatum (C) and hippocampus (D) of MCAO and Sham experimental groups. Expression of BCL11B was higher in MCAO operated animals, in all of the analyzed regions, except contralateral hippocampus. (E) Integrated optical density of BCL11B calculated for whole brain hemispheres and entire brain of MCAO and Sham experimental groups showing higher levels of BCL11B. The statistical significance was tested using nested ANOVA followed by Tukey’s multiple comparisons correction. Data are presented as mean ± standard deviation. ***P < 0.001.

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