Figure 4:

3xTg Inceptor is detectable in the aged mouse brain and reduced in the 3xTg (AD) hypothalamus but not hippocampus or cortex. 40-week-old female mouse hypothalamus tissue was assessed by western blot for Inceptor, Insulin Receptor (IR), and IGF1 Receptor (IGF1R) (a), and quantified compared to actin (b). Hippocampus and cortex tissue from the same animals was measured for Inceptor (c) and quantified compared to actin (d). Unpaired t-test was used to determine statistical significance with p < 0.05.