Table 2 Changes in hemodynamic responses and heart rate variability during bladder hydrodistention between the two groups.

From: Autonomic responses during bladder hydrodistention under general versus spinal anaesthesia in patients with interstitial cystitis/bladder pain syndrome: a randomized clinical trial

 

GA group

(n = 18)

SA group

(n = 18)

Median, mean, or proportion difference [95% CI]

P value

Differences between max and baseline

 ΔSBP (mmHg)

73.0 [26.0–86.0]

2.0 [− 4.0 to 6.0]

− 71.0 [− 84.0, − 30.5]

 < 0.001

 SBP increase > 20%

14 (77.8%)

0 (0.0%)

− 77.8% [− 91.0%, − 48.9%]

 < 0.001

 ΔDBP (mmHg)

42.5 [24.0–56.0]

3.0 [− 2.0 to 6.0]

− 39.5 [− 53.0, − 22.0]

 < 0.001

 ΔMBP (mmHg)

42.9 ± 28.3

− 1.4 ± 29.0

− 44.4 [− 63.8, − 25.0]

 < 0.001

 ΔHR (beat per min)

18.6 ± 19.6

3.5 ± 14.9

− 15.1 [− 26.9, − 3.2]

0.014

Baseline valuesa

 SBP (mmHg)

96.5 [90.0 − 110.0]

140.5 [131.0–172.0]

47.9 [31.1, 64.7]

 < 0.001

 DBP (mmHg)

53.7 ± 12.7

75.3 ± 9.8

21.6 [13.9, 29.2]

 < 0.001

 MBP (mmHg)

70.6 ± 13.7

100.3 ± 18.3

29.7 [18.8, 40.7]

 < 0.001

 HR (beat per min)

67.1 ± 11.9

70.8 ± 14.4

3.8 [− 5.2. 12.7]

0.396

Maximum values during hydrodistention

 SBP (mmHg)

159.7 ± 38.0

145.7 ± 22.7

− 14 [− 35.4, 7.4]

0.191

 DBP (mmHg)

93.2 ± 26.5

74.6 ± 10.0

− 18.6 [− 32.5, − 4.8]

0.011

 MBP (mmHg)

113.5 ± 30.2

104.7 ± 20.4

− 8.9 [− 26.6, 8.9]

0.320

 HR (beat per min)

85.6 ± 19.5

74.3 ± 15.4

− 11.3 [− 23.2, 0.6]

0.063

HRV before bladder hydrodistention

 RMSSD (ms)

12.1 [6.5–32.7]

19.3 [13.2–29.4]

7.2 [− 22.1, 19.4]

0.233

 SDNN (ms)

14.1 [8.8–26.3]

20.5 [15.2–32.8]

6.4 [− 8.4, 20.4]

0.486

 LF/HF ratio

2.5 [1.3–6.7]

2.3 [0.5–12.8]

− 0.2 [− 5.8, 7.0]

0.935

HRV after bladder hydrodistention

 RMSSD (ms)

10.8 [7.7–19.8]

20.6 [15.1–44.7]

9.8 [− 2.6, 34.9]

0.045

 SDNN (ms)

14.4 [10.0–22.3]

18.5 [11.8–38.3]

4.2 [− 6.2, 23.1]

0.367

 LF/HF ratio

1.2 [0.3–11.0]

1.4 [0.4–3.5]

0.1 [− 7.3, 1.9]

0.787

  1. GA, general anaesthesia; SA, spinal anaesthesia; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; HR, heart rate; RMSSD, root-mean-square of successive differences; SDNN, standard deviation of normal-to-normal interval; LF/HF ratio, low-frequency/high-frequency ratio.
  2. aMeasured 5 min after the induction of anaesthesia.