Table 3 Comparison of anaesthetic and operational findings between the two groups.

From: Autonomic responses during bladder hydrodistention under general versus spinal anaesthesia in patients with interstitial cystitis/bladder pain syndrome: a randomized clinical trial

 

GA group

(n = 18)

SA group

(n = 18)

Median, mean, or proportion difference [95% CI]

P value

Bupivacaine dose (mg)

N/A

12.9 ± 1.4

N/A

N/A

Sensory block levela

N/A

T7 [T6–T8]

N/A

N/A

Volatile agent (MAC)a

0.9 [0.7–1.0]

N/A

N/A

N/A

Remifentanil concentration (ng/mL)a

5.3 [4.0–6.0]

N/A

N/A

N/A

Use of rescue vasopressorb

14 (77.8%)

0 (0.0%)

− 77.8% [− 91.0%, − 48.9%]

 < 0.001

 During induction

5 (27.8%)

0 (0.0%)

− 27.8% [− 50.9%, 4.5%]

0.018

 Before bladder hydrodistention

6 (33.3%)

0 (0.0%)

− 33.3% [− 56.2%, − 8.8%]

0.008

 After bladder hydrodistention

8 (44.4%)

0 (0.0%)

− 44.4% [− 66.2%, 17.9%]

0.002

Use of rescue vasodilator

5 (27.8%)

1 (5.6%)

−  22.2% [− 45.8%, 3.1%]

0.178

MAC during hydrodistention

 Remifentanil concentration

  Surgery time (min)

31.9 ± 12.0

32.2 ± 9.8

0.3 [− 7.1, 7.7]

0.928

  Anaesthesia time (min)

57.2 ± 13.0

59.7 ± 11.4

2.4[− 5.8, 10.7]

0.551

  Postoperative outcomes

   PACU stay time (min)

40.0 [39.0–41.0]

30.5 [24.0–56.0]

− 9.5 [− 15.5, 15.0]

0.193

   Pain score in PACU (NRS)

3.5 [0.0–5.5]

0.0 [0.0–0.0]

− 3.5 [− 4.8, 0.0]

 < 0.001

   Use of analgesics in PACU

2 (11.1%)

0 (0.0%)

−  11.1% [− 32.8%, 8.2%]

0.486

Cystoscopic findings

Hunner’s lesions

17 (94.4%)

15 (83.3%)

11.1% [− 11.8%, 34.1%]

0.596

 Glomerulation

6 (33.3%)

3 (16.7%)

16.6% [− 11.7%, 42.0%]

0.441

 Mucosal rainy bleeding

3 (16.7%)

10 (55.6%)

38.9% [7.5%, 61.5%]

0.037

  1. GA, general anaesthesia; SA, spinal anaesthesia; N/A, not applicable; PACU, post-anaesthesia care unit; NRS, numeric rating scale.
  2. aMeasured before hydrodistention.
  3. bIn some cases, multiple doses of vasopressors were administered.