Figure 1

Neuromuscular function is not affected in Syn1Cre mice. Average latency to fall during four days of training in the Rotarod revealed no significant difference in motor learning over time in male (a) or female (b) Syn1Cre mice. Analysis of body weight adjusted front-paw grip strength revealed no significant difference in strength of male (c) or female (d) Syn1Cre mice. Analysis of all four paws showed no significant difference in male Syn1Cre mice (e), but a significant reduction in body weight-adjusted strength of all four paws in female Syn1Cre mice was detected (f). Exploration in a non-aversive arena were not significantly different in Syn1Cre mice (g). No significant difference was detected in locomotion speed during exploration of a non-aversive arena in Syn1Cre mice (h). Number of animals reported at the bottom of the bars for each condition. All error bars correspond to standard deviation of the mean except for longitudinal rotarod where standard error of the mean is reported. For ANCOVA analysis the 95% confidence interval is plotted. Asterisks denote the following: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. For detailed statistical values see Supplementary Table S1.