Figure 2

Exploratory and anxiety-like behaviour in Syn1Cre mice. (a) Locomotor activity and (b) locomotor speed in the open field arena were significantly reduced in Syn1Cre mice. (c) Rearing behaviour was significantly reduced in Syn1Cre mice. (d) Male but not female Syn1Cre mice showed reduced centre occupancy. (e) Centre ambulation normalised to total distance measured in the non-aversive arena revealed no significant difference in Syn1Cre mice. Number of animals reported at the bottom of the bars. All error bars correspond to standard deviation of the mean. Interaction between genotype and sex was analysed by two-way ANOVA, followed by Sidaks post hoc test. Asterisks denote the following: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. For detailed statistical values see Supplementary Table S1.