Figure 3

Spatial reference memory and working memory of Syn1Cre mice. (a) Number of alternations during the spontaneous Y-maze assay revealed no significant difference in Syn1Cre mice. (b) Number of correct A > B > C alternations as a percentage of total alternations did not show any significant difference in Syn1Cre mice. (c) Assessment of escape latency across nine trials of water maze training showed significant reduction in learning of male Syn1Cre mice. (d) Assessment of escape latency across 12 trials of water maze training showed no significant difference in female Syn1Cre mice (female wild type n = 19 and Syn1Cre n = 20). (e) Probe trial quadrant occupancy revealed a significant reduction in target quadrant occupancy in male Syn1Cre mice compared to wild type littermates (male wild type n = 19 and Syn1Cre n = 20). (f) Probe trial quadrant occupancy revealed no memory in female wild type or Syn1Cre mice (female wild type n = 19 and Syn1Cre n = 20). (g) Platform crossings during probe trial revealed presence of long-term memory exclusively in male wild type mice. (h) Latency to escape in the cued water maze revealed significant sex-specific increase of time in male Syn1Cre mice. Number of animals reported at the bottom of the bars where possible, otherwise in the figure legend. All error bars correspond to standard deviation of the mean except water maze training where standard error of the mean was plotted. Asterisks denote the following: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. For detailed statistical values see Supplementary Table S1.