Figure 4 | Scientific Reports

Figure 4

From: Multi-landmark alignment of genomic signals reveals conserved expression patterns across transcription start sites

Figure 4

RNA polymerase II occupancy, DNA accessibility, and H3K4me3 epigenetic chemical modification of the histone H3 protein in K562 leukemia cell lines shows a complex dependence on the distance from pairs of TSSs and the transcriptional activity of the gene. (A, B, C), two-dimensional density of POLR2A ChIP-seq signal (A), DNase-seq signal (B), H3K4me3 ChIP-seq signal (C) for pairs of the first (TSS 1) and second (TSS 2) TSSs of genes with high, medium, and low levels of transcription. Data is available from the ENCODE consortium (experiment accession numbers ENCSR000FAJ, Sherman Weissman lab, Yale; ENCSR000EKS, Gregory Crawford lab, Duke; ENCSR000AKU and Bradley Bernstein, Broad). The accession numbers of the POLR2A ChIP-seq signal, DNase-seq signal, H3K4me3 ChIP-seq signal, and gene quantifications are ENCFF000YWY, ENCFF000SVL, ENCFF000BYB, and ENCFF782PCD, respectively.

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