Table 1 Evaluation of different filtering strategies for Qiaseq variant calls using the Oncomine calls in the common regions as ground truth.

From: Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels

 

Precision

Recall

F1 score

MCC

Youden’s J

No filtering

0.07

1

0.12

0

0

Rule-based filtering

0.12

0.33

0.17

0.17

0.19

SVM-based filtering

0.36

0.35

0.35

0.34

0.33

Post-processing filtering only

0.20

0.4

0.26

0.23

0.22

  1. MCC Matthews correlation coefficient, SVM support vector machine.