Figure 6 | Scientific Reports

Figure 6

From: Intrinsic brain connectivity alterations despite intact pain inhibition in subjects with neuropathic pain after spinal cord injury: a pilot study

Figure 6

Stronger rsFC between brainstem region and visual cortex is related to lower CPM efficiency in SCI-NP subjects. Significant group differences in correlations with CPM efficiency and rsFC between the right vlPAG and bilateral occipital cortex. (a) Seed region for seed-to-voxel rsFC analysis. (b) Significant group interactions in relation to CPM efficiency and rsFC between the seed region and clusters of the lateral occipital cortex bilaterally. MNI co-ordinates are provided and clusters were significant at p < 0.05 FWE-level corrected. (c, d) Scatter plot representation of correlations between CPM effect and rsFC strength in each group (z-scores are Fisher transformed correlation coefficients). Individual CPM effect is described as negative and positive numbers, which indicate pain inhibition and facilitation, respectively. Pearson r value is also provided for visualisation. CPM, conditioned pain modulation; FWE, family-wise error; HC, healthy controls; L, left; MNI, Montreal Neurological Institute; NP, neuropathic pain; NRS, numerical rating scale; R, right; SCI-NP, spinal cord injury and neuropathic pain; TS-CPM, test stimulus under CPM; TS-Sham, test stimulus under Sham condition; vlPAG, ventrolateral periaqueductal gray.

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