Table 1 Summary of activating agents and traction force generation on soft substrates.

From: Mechanosensitive traction force generation is regulated by the neutrophil activation state

Summary of traction force generation

Activating agent

Effect on traction forces

Differential in/out-of-plane?

Mechanosensitive to stiffness?

PMA

\(\Uparrow \Uparrow\)

–

Yes

LPS

–

–

–

Cytokines

\(\Downarrow\)

Yes

Yes

LPS + Cytokines

–

Yes

Yes

fMLF

–

–

–

fMLF + Priming

\(\Uparrow\)

–

–

  1. (Left) Summary of every pharmacological activating agent and its effect on traction forces on soft substrates, (Center) and if that effect is differentially regulated in-plane versus out-of-plane to the soft substrate. (Right) Summary of every pharmacological activating agent and if it’s aforementioned trend differs on stiff substrate.
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