Table 3 Profile of plasmids with two or more KPC-2 core structures.

The tandem repeats of two or more KPC-2 core structures

 F94 plasmid pA (OM144977.1)

2

IS26-(ISKpn6-bla_KPC-2-ISKpn27-tnpR2-IS26)-(ISKpn6-bla_KPC-2-ISKpn27-tnpR3-IS26)

Taizhou Municipal Hospital affiliated with Taizhou University

 pKPC-J5501 (OL891656.1)

2

(IS26-tnpR3-ISKpn27-bla_KPC-2-ISKpn6) -(IS26-tnpR3-ISKpn27-bla_KPC-2-ISKpn6)-IS26

Yongchuan Hospital of Chongqing Medical University

 pBSI014-KPC2 (MT269822.1)

2

IS26-(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)- (ISKpn6-bla_KPC-2-ISKpn27-tnpR3-IS26)

Sun Yat-sen University, Guangzhou

 pKPC2_020037 (CP036372.1)

2

IS26-(ISKpn6-bla_KPC-2-ISKpn27-tnpR2-IS26)- (ISKpn6-bla_KPC-2-ISKpn27-tnpR3-IS26)

West China Hospital, Sichuan University, Chengdu

 pKPC2_020002 (CP028541.2)

3

IS26-(ISKpn6-bla_KPC-2-ISKpn27-tnpR2-IS26)- (ISKpn6-bla_KPC-2-ISKpn27-tnpR3-IS26)- (ISKpn6-bla_KPC-2-ISKpn27-tnpR1-IS26)

West China Hospital, Sichuan University, Chengdu

Repeats of two or more KPC-2 core structure separated by 2–5 genes or orfs

 pKPC2_115011 (CP089954.1)

2

(IS26-ISKpn6-bla_KPC-2-ISKpn27-tnpR)-orf1-orf2-(IS26-ISKpn6-bla_KPC-2-ISKpn27-tnpR)

West China Hospital, Sichuan University, Chengdu

 pSH9-KPC (MH255827.1)

5

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)-klcA-orf-(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)-klcA-orf-(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)-klcA-orf-(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)-klcA-orf- (ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Hongkong Polytechnic University, Hongkong

 pPA30_2 (CP104872.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR) -orf1-orf2-orf3-orf4-(ISKpn6-bla_KPC-2-ISKpn27-tnpR)

Sir Run Run Shaw Hospital, Hangzhou

 pU1121 (ON614169.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR) -orf1-orf2-orf3-orf4-(ISKpn6-bla_KPC-2-ISKpn27-tnpR)

The first affiliated Hospital of Zhejiang University, Hangzhou

 pSRRSH1002-KPC (CP064398.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR) -orf1-orf2-orf3-orf4-(ISKpn6-bla_KPC-2-ISKpn27-tnpR)

Sir Run Run Shaw Hospital, Hangzhou

 Plasmid YLH6_p3 (MK882885.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR) -orf1-orf2-orf3-orf4-(ISKpn6-bla_KPC-2-ISKpn27-tnpR)

Sir Run Run Shaw Hospital, Hangzhou

 pHS20R14-KPC-2 (CP064771.1)

3

(tnpR-ISKpn27-bla_KPC-2-ISKpn6)-orf1-klcA-orf2-orf3-orf4-(tnpR-ISKpn27-bla_KPC-2-ISKpn6)-orf1-klcA-orf2-orf3-orf4- (tnpR-ISKpn27-bla_KPC-2-ISKpn6)

Huashan Hospital, Shanghai

 Strain PA30 chr (CP102441.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR) -orf1-orf2-orf3-orf4-(tnpR-ISKpn27-bla_KPC-2-ISKpn6)

Sir Run Run Shaw Hospital, Hangzhou

 Strain XHKPN391 chr (P066915.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26) -orf1-klcA-orf2-(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Xinhua Hospital, Shanghai

Two or more KPC-2 core structures spaced apart from each other

 pXHKP309-1 (CP066901.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26) // (IS26-ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Xinhua Hospital, Shanghai

 pKPC-063001 (MZ156798.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26) // (IS26-ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Yongchuan Hospital of Chongqing Medical University

 pE0171_KPC (MK370988.1)

2

(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6) // (IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6)

Chinese Academy of Sciences, Beijing

 pA1836-KPC (MT810353.1)

3

(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6) // (tnpR-ISKpn27-bla_KPC-2-ISKpn6) //(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6)

Institute of Microbiology and Epidemiology, Beijing

 pE02162_KPC (MK370991.1)

3

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26) //(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)//(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Chinese Academy of Sciences, Beijing

 Plasmid unnamed4 (CP097674.1)

2

(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26) //(ISKpn6-bla_KPC-2-ISKpn27-tnpR)

PLA General Hospital, Beijing

 pJNKPN52_KPC_FOS (MZ512197.1)

2

(bla_KPC-2-ISKpn27-tnpR-IS26) //(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6)

Shandong Provincial Hospital, Jinan

 Plasmid unnamed2 (MZ475694.1)

2

(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6) //(tnpR-bla_KPC-2-ISKpn6)

Huashan Hospital, Shanghai

 pSH2-85K-MDR (MH643792.1)

2

(IS26-tnpR-ISKpn27-bla_KPC-2) //(ISKpn6-bla_KPC-2-ISKpn27-tnpR-IS26)

Hongkong Polytechnic University, Hongkong

 pBSI039-KPC2 (MT269828.1)

2

orf1-bla_KPC-2-orf2-(IS26-tnpR-ISKpn27-bla_KPC-2-ISKpn6) //(bla_KPC-2-ISKpn27-tnpR-IS26)

Sun Yat-sen University, Guangzhou