Table 1 PK parameters for BSR and EXR doses.

C_max (ng/mL)

1.82 ± 0.74

1.43 ± 0.82

2.14 ± 0.52

2.51 ± 0.97

T_max (h)

6.25 ± 3.24

13.33 ± 8.26

8 ± 0

10 ± 5.66

T_last (h)

72 ± 0

72 ± 0

72 ± 0

72 ± 0

t_1/2 (h)

36.71 ± 17.88

21.57 ± 14.86

24.24 ± 4.74

22.71 ± 13.48

AUC_0–Tlast (ng × h/mL)

55.48 ± 18.52

47.02 ± 13.02

67.37 ± 2.45

86.52 ± 27.51

AUC_0–∞ (ng × h/mL)

73.73 ± 28.85

59.28 ± 10.04

77.28 ± 1.91

105.94 ± 39.97

Clearance (L/h/kg)

2.26 ± 0.68

1.73 ± 0.34

1.94 ± 0.05

2.14 ± 0.83

k_e (L/h)

0.023 ± 0.011

0.041 ± 0.019

0.029 ± 0.006

0.037 ± 0.013

MRT (h)

25.2 ± 2.89

25.66 ± 6.32

24.35 ± 2.94

25.13 ± 6.05

MRT_0–∞ (h)

50.9 ± 24.19

33.6 ± 21.66

35.03 ± 7.35

34.57 ± 18.72